A multilayered defense against infection: combinatorial control of insect immune genes.

@article{Uvell2007AMD,
  title={A multilayered defense against infection: combinatorial control of insect immune genes.},
  author={Hanna Uvell and Ylva Engstr{\"o}m},
  journal={Trends in genetics : TIG},
  year={2007},
  volume={23 7},
  pages={342-9}
}
The innate immune defense system involves the activity of endogenous antimicrobial peptides (AMPs), which inhibit the growth of most microbes. In insects, genes encoding AMPs are expressed at basal levels in barrier epithelia and are upregulated systemically in response to infection. To achieve this differentiated immune defense, Drosophila immune gene promoters combine tissue-specific enhancers and signal-dependent response elements. Transcription factors of the Hox, POU and GATA families… CONTINUE READING

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