A multifunctional neurotrophin with reduced affinity to p75NTR enhances transplanted Schwann cell survival and axon growth after spinal cord injury

@article{Enomoto2013AMN,
  title={A multifunctional neurotrophin with reduced affinity to p75NTR enhances transplanted Schwann cell survival and axon growth after spinal cord injury},
  author={Mitsuhiro Enomoto and Mary Bartlett Bunge and Pantelis Tsoulfas},
  journal={Experimental Neurology},
  year={2013},
  volume={248},
  pages={170-182}
}
The lack of regeneration of axonal pathways after SCI is associated with the presence of inhibitory molecules within the glial scar, the loss of the neuron's intrinsic capacity to grow and the absence of growth factors. The NGF family of neurotrophins is a potent growth factor for several types of supraspinal and sensory axons. It is unclear, however, whether the neurotrophin's axon growth-promoting activities after central nervous system (CNS) injuries are mediated through the Trk receptors or… CONTINUE READING
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