A multicopy dinucleotide marker that maps close to the spinal muscular atrophy gene.

@article{Burghes1994AMD,
  title={A multicopy dinucleotide marker that maps close to the spinal muscular atrophy gene.},
  author={Arthur H M Burghes and Susan E. Ingraham and Michael McLean and Terri Thompson and John D. McPherson and Zsofia Kote-Jarai and John D. Carpten and Christine J DiDonato and Joh E Ikeda and Linda C Surh},
  journal={Genomics},
  year={1994},
  volume={21 2},
  pages={394-402}
}
Spinal muscular atrophy (SMA) is a common autosomal recessive disorder resulting in loss of motor neurons. The interval containing the SMA gene has been defined by linkage analysis as 5qcen-D5S435-SMA-D5S557-5qter. We have isolated a new dinucleotide repeat marker, CATT1, that lies between these two closest markers. The marker CATT1 has 16 alleles and is highly polymorphic. The marker can have 1 to 4 (or more) copies per chromosome, giving rise to individuals with up to 8 (or more) alleles. All… CONTINUE READING

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