A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s.

@article{Andersen1997AMG,
  title={A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s.},
  author={Melvin E. Andersen and Christopher R Eklund and J J Mills and Hugh A. Barton and Linda S Birnbaum},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={144 1},
  pages={135-44}
}
A geometric, multicompartment model of the liver was developed to examine regional protein induction and to provide model output suitable for predicting the degree of induction in both the whole liver and in specific regions. The model was based on functional hexagonal arrays within the liver. A geometric representation was used to divide these functional units into five zones: a concentric periportal zone, a fenestrated periportal region that interconnects among multiple functional units, and… CONTINUE READING

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