A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.

@article{Zhang2021AME,
  title={A multiclade env-gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques.},
  author={Peng Zhang and Elisabeth Narayanan and Qingbo Liu and Yaroslav I Tsybovsky and Kristin L. Boswell and Shilei Ding and Zonghui Hu and Dean A. Follmann and Yin Lin and Huiyi Miao and Hana Schmeisser and Denise Rogers and Samantha Falcone and Sayda M. Elbashir and Vladimir Presnyak and Kapil Bahl and Madhu S. Prabhakaran and Xuejun Chen and Edward K. Sarfo and David R. Ambrozak and Rajeev Gautam and MA Martin and Joanna Swerczek and Richard Herbert and Deborah E. Weiss and Johnathan Misamore and Giuseppe Ciaramella and Sunny Himansu and Guillaume B. E. Stewart-Jones and Adrian B. McDermott and Richard A. Koup and John R. Mascola and Andr{\'e}s Finzi and Andrea Carfi and Anthony S. Fauci and Paolo Lusso},
  journal={Nature medicine},
  year={2021}
}
The development of a protective vaccine remains a top priority for the control of the HIV/AIDS pandemic. Here, we show that a messenger RNA (mRNA) vaccine co-expressing membrane-anchored HIV-1 envelope (Env) and simian immunodeficiency virus (SIV) Gag proteins to generate virus-like particles (VLPs) induces antibodies capable of broad neutralization and reduces the risk of infection in rhesus macaques. In mice, immunization with co-formulated env and gag mRNAs was superior to env mRNA alone in… 

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