A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy.

@article{Einarson2003AMP,
  title={A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy.},
  author={Adrienne RN Einarson and Lori Bonari and Sharon Voyer-Lavigne and Antonio Addis and Doreen Matsui and Yvette R. Johnson and Gideon Koren},
  journal={Canadian journal of psychiatry. Revue canadienne de psychiatrie},
  year={2003},
  volume={48 2},
  pages={106-10}
}
OBJECTIVES Trazodone and nefazodone are phenylpiperazine antidepressants. Currently, there are no adequate, well-controlled studies on the fetal safety of these drugs. Our primary objective was to determine whether the use of trazodone or nefazodone during pregnancy is associated with an increased risk for major malformations. Secondary outcomes of interest included rates of spontaneous and therapeutic abortions, rates of premature labour, and birth weight. METHODS Pregnant women from 5… CONTINUE READING
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