A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis.

@article{Kruger2013AMR,
  title={A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis.},
  author={Peter S Kruger and M. Bailey and Rinaldo Bellomo and David Jamie Cooper and Meg L Harward and A. Higgins and Belinda D Howe and Darryl S. Jones and Chris Joyce and Karam Maximilien Kostner and John McNeil and Alistair D Nichol and Michael S. Roberts and Gillian A Syres and Bala Venkatesh},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={187 7},
  pages={743-50}
}
RATIONALE Observational studies link statin therapy with improved outcomes in patients with severe sepsis. OBJECTIVES To test whether atorvastatin therapy affects biologic and clinical outcomes in critically ill patients with severe sepsis. METHODS Phase II, multicenter, prospective, randomized, double-blind, placebo-controlled trial stratified by site and prior statin use. A cohort of 250 critically ill patients (123 statins, 127 placebo) with severe sepsis were administrated either… CONTINUE READING

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