A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome.

@article{Hudak1996AMR,
  title={A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome.},
  author={Mark Lawrence Hudak and Elaine E. Farrell and Adam A. Rosenberg and August L Jung and Richard L Auten and David J. Durand and Michael Horgan and Sharon Buckwald and Marc R Belcastro and Pamela K. Donohue and Vivien Carrion and W W Maniscalco and Michael J Balsan and Barbara A. Torres and Randy R Miller and Robert D Jansen and Janet E. Graeber and K M Laskay and E J Matteson and Edward A. Egan and Alan S. Brody and David J. Martin and Merchline M Riddlesberger and Paul Montgomery},
  journal={The Journal of pediatrics},
  year={1996},
  volume={128 3},
  pages={396-406}
}
OBJECTIVE To compare the efficacy and safety of two surfactant preparations in the treatment of respiratory distress syndrome (RDS). METHODS We conducted a randomized, masked comparison trial at 21 centers. Infants with RDS who were undergoing mechanical ventilation were eligible for treatment with two doses of either a synthetic (Exosurf) or natural (Infasurf) surfactant if the ratio of arterial to alveolar partial pressure of oxygen was less than or equal to 0.22. Crossover treatment was… CONTINUE READING

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