A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age

@article{Chang2004AMI,
  title={A multicenter in vivo proton-MRS study of HIV-associated dementia and its relationship to age},
  author={L. Chang and P. L. Lee and Constantin Theodore Yiannoutsos and Thomas Ernst and Christina M. Marra and Todd L. Richards and Dennis L. Kolson and Giovanni Schifitto and Jeffrey G. Jarvik and Eric Miller and Robert E. Lenkinski and G. Gonzalez and Bradford Navia and H. I. V. Mrs Consortium},
  journal={NeuroImage},
  year={2004},
  volume={23},
  pages={1336-1347}
}

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TLDR
Findings indicate that despite the widespread use of HAART, HIV-associated cognitive impairment and brain injury persist in the setting of chronic and stable disease.

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TLDR
The results highlight the importance of white matter involvement in HIV-associated dementia and support the current pathogenesis model of glial cell proliferation in HIV infection, denoted by regional Cho elevations, and neuronal dysfunction and/or death, denoting by NAA decreases, associated with dementia.

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TLDR
It is shown for the first time that host and viral factors related to both current and past HIV status contribute to persisting cerebral metabolite abnormalities and provide a framework for further understanding neurological injury in the setting of chronic and stable disease.

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TLDR
The findings here support prevention of the encephalitic process, but suggest that suppressing the formation of multinucleated giant cells alone would be insufficient to prevent neuronal injury.

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TLDR
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TLDR
Overall, HAND showed specific alterations (more aWM and inflammation; less gray matter volume and lower NAA); some MR measures differentiated less severe subtypes of HAND from HAD.

Imaging Neuroinflammation? A Perspective from MR Spectroscopy

TLDR
The current results suggest that competing mechanisms can influence in vivo Cho and mI levels, and that elevations in these metabolites cannot necessarily be interpreted as reflecting a single underlying mechanism, including neuroinflammation.

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TLDR
Widespread progressive changes in the brain, including neuronal injury, occur in chronically HIV-infected persons despite stable antiretroviral treatment and virologic suppression and can lead to neurocognitive declines.

Magnetic Resonance Spectroscopy in HIV-Associated Brain Injury

This chapter describes the different methods used to perform magnetic resonance spectroscopy (MRS) studies of patients with HIV infection, reviews the major findings from the studies, and identifies
...

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