A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures.

@article{Aldenkamp2000AMR,
  title={A multicenter, randomized clinical study to evaluate the effect on cognitive function of topiramate compared with valproate as add-on therapy to carbamazepine in patients with partial-onset seizures.},
  author={Albert P. Aldenkamp and Gus A. Baker and Olaf G. Mulder and David P. Chadwick and Peter Cooper and Jan C. Doelman and Roderick Duncan and Cristiana Gassmann-Mayer and Gerrit-Jan de Haan and Charlotte Hughson and Jacques Hulsman and J. A. Overweg and Gordon Pledger and Th. W Rentmeester and Hamira Riaz and Steve Wroe},
  journal={Epilepsia},
  year={2000},
  volume={41 9},
  pages={
          1167-78
        }
}
PURPOSE This study compares the cognitive effects of topiramate (TPM) with those of valproate (VPA) using efficacious doses of each drug when used as adjunctive therapy to carbamazepine (CBZ). A key question of the study is to what extent a more gradual introduction of TPM improves tolerability and prevents cognitive impairment. METHODS The study is a multicenter, randomized, observer-blinded, parallel-group clinical trial with VPA or TPM given as first-line add-on therapy to steady-state… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 47 CITATIONS

[Cognitive effects of therapy with topiramate in patients with refractory partial epilepsy].

  • Revista de neurologia
  • 2002
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Epilepsy and Intellectual Disabilities

  • Springer International Publishing
  • 2016
VIEW 1 EXCERPT
CITES METHODS

Similar Papers

Loading similar papers…