A multicenter, randomized, open-label, controlled study comparing the efficacy, safety and cost-effectiveness of a sequential therapy with RV4104A ointment, ciclopiroxolamine cream and ciclopirox film-forming solution with amorolfine nail lacquer alone in dermatophytic onychomycosis.

@article{Paul2013AMR,
  title={A multicenter, randomized, open-label, controlled study comparing the efficacy, safety and cost-effectiveness of a sequential therapy with RV4104A ointment, ciclopiroxolamine cream and ciclopirox film-forming solution with amorolfine nail lacquer alone in dermatophytic onychomycosis.},
  author={C. Paul and D. Coustou and Morad Lahfa and Cristina Bulai-Livideanu and Nejib Doss and I Mokthar and Hamida Turki and Rafia B Nouira and B{\'e}cima Fazaa and Abel Ben Osman and Othar Zourabichvili and Christine Cazeau and H{\'e}la Coubetergues and St{\'e}phane Picot and Anne Lise Bienvenu and Jean Jacques Voisard},
  journal={Dermatology},
  year={2013},
  volume={227 2},
  pages={
          157-64
        }
}
BACKGROUND The efficacy of topical antifungals is controversial. OBJECTIVE To compare the efficacy and safety of a sequential(SEQ) treatment with chemical nail avulsion and topical antifungals to amorolfine nail lacquer in dermatophytic onychomycosis. METHODS This was a randomized,parallel-group, controlled study comparing a 36-week SEQ treatment with chemical nail avulsion with RV4104A ointment(class I medical device containing 40% urea) followed by ciclopirox cream for 8 weeks and… CONTINUE READING
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