A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis

@inproceedings{Wei2009AMD,
  title={A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis},
  author={Wei Wei and Ling-ling Zhang and Jian-hua Xu and Feng Xiao and Chun-de Bao and L Ni and Xing-fu Li and Yu-qing Wu and Lingyun Sun and Ronghua Zhang and Baoliang Sun and Sheng-qian Xu and Shang Wen Liu and Wei Zhang and Jie Shen and Hua-xiang Liu and Ren-Cheng Wang},
  booktitle={Arthritis research & therapy},
  year={2009}
}
INTRODUCTION Chicken type II collagen (CCII) is a protein extracted from the cartilage of chicken breast and exhibits intriguing possibilities for the treatment of autoimmune diseases by inducing oral tolerance. A 24-week, double-blind, double-dummy, randomized, methotrexate (MTX)-controlled study was conducted to evaluate the efficacy and safety of CCII in the treatment of rheumatoid arthritis (RA). METHODS Five hundred three RA patients were included in the study. Patients received either 0… CONTINUE READING
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