Corpus ID: 36928087

A multi-scale model of stem cell niche formation inside intestine crypts

  title={A multi-scale model of stem cell niche formation inside intestine crypts},
  author={Stefan Janssen and Lo{\"i}c Paulev{\'e} and Y. Ponty and Balaji Raman and M. Zytnicki},
s Table of 

Figures and Tables from this paper


Organizing cell renewal in the intestine: stem cells, signals and combinatorial control
A flurry of recent papers has clarified the key regulatory signals and brought us to the point where the authors can begin to give a coherent account, for at least one tissue, of how these signals collaborate to organize the architecture and behaviour of a stem-cell system. Expand
Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
Quantitative analysis shows that stem cell turnover follows a pattern of neutral drift dynamics, consistent with a model in which the resident stem cells double their numbers each day and stochastically adopt stem or TA fates. Expand
Notch signalling in solid tumours: a little bit of everything but not all the time
The discovery of Notch in Drosophila melanogaster opened the door to an ever-widening understanding of cellular processes that are controlled or influenced by Notch signalling, and a role for Notch is well established in haematological malignancies. Expand
Analysis and verification of the HMGB1 signaling pathway
A rule-based model of crosstalk between the HMGB1 signaling pathway and other key cancer signaling pathways is developed and shows that, ifHMGB1 is overexpressed, then the oncoproteins CyclinD/E, which regulate cell proliferation, are overexpression, while tumor suppressor proteins that regulate cell apoptosis (programmed cell death), such as p53, are repressed. Expand
Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning
Both model systems show how mutual inactivation can facilitate robust fine-grained patterning processes that would be difficult to implement without it, by encoding a difference-promoting feedback within the signaling system itself. Expand
Computational tools for the synthetic design of biochemical pathways
Key existing tools for de novo design of biosynthetic pathways and suggestions for how informatics can help to shape the future of synthetic microbiology are offered. Expand
Asmparts: assembly of biological model parts
A new computational tool to produce models of biological systems by assembling models from biological parts, which takes advantage of modularity and enforces standardisation in part characterisation by considering a model of each part. Expand
Computational design approaches and tools for synthetic biology.
This work states that the use of computer aided design tools should eventually become centrally important to the field of synthetic biology if the challenge of dealing with the stochasticity and complexity of biological systems can be overcome. Expand
TinkerCell: modular CAD tool for synthetic biology
An ideal CAD application for engineering biological systems would provide features such as: building and simulating networks, analyzing robustness of networks, and searching databases for components that meet the design criteria. Expand
Complete Chemical Synthesis , Assembly , and Cloning of a Mycoplasma genitalium Genome
This article presents a meta-analyses of the determinants of infectious disease in eight distinct germ cell types and shows clear patterns in response to EMT and “cell reprograming”. Expand