A multi-phase mathematical model of quorum sensing in a maturing Pseudomonas aeruginosa biofilm.

@article{Anguige2006AMM,
  title={A multi-phase mathematical model of quorum sensing in a maturing Pseudomonas aeruginosa biofilm.},
  author={Keith Anguige and John R. King and John P. Ward},
  journal={Mathematical biosciences},
  year={2006},
  volume={203 2},
  pages={240-76}
}
It is well known that sessile bacteria have a strong tendency to exist in a biofilm phenotype, whereby bacterial cells aggregate and produce a gel-like extracellular matrix, which, in an infection scenario, offers a significant barrier to attack by conventional antibiotics and the immune system. In this paper we develop a multi-phase model of a maturing Pseudomonas aeruginosa biofilm, allowing for the production and secretion of exopolysaccharide (EPS). The primary quorum-sensing system of P… CONTINUE READING

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