A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.

@article{Tukiainen2008AMA,
  title={A multi-metabolite analysis of serum by 1H NMR spectroscopy: early systemic signs of Alzheimer's disease.},
  author={Taru Tukiainen and Tuulia Tynkkynen and Ville-Petteri M{\"a}kinen and Pasi Jyl{\"a}nki and Antti J. Kangas and Johanna Hokkanen and Aki Vehtari and Olli Gr{\"o}hn and Merja Hallikainen and Hilkka Soininen and Miia Kivipelto and Per-Henrik Groop and Kimmo K. Kaski and Reino Laatikainen and Pasi Soininen and Tuula A Pirttil{\"a} and Mika Ala-Korpela},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={375 3},
  pages={356-61}
}
A three-molecular-window approach for (1)H NMR spectroscopy of serum is presented to obtain specific molecular data on lipoproteins, various low-molecular-weight metabolites, and individual lipid molecules together with their degree of (poly)(un)saturation. The multiple data were analysed with self-organising maps, illustrating the strength of the approach as a holistic metabonomics framework in solely data-driven metabolic phenotyping. We studied 180 serum samples of which 30% were related to… CONTINUE READING
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