A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.

Abstract

Aromatic rings, ubiquitous in pharmaceutical compounds, are often exchanged with another ring during the optimization process of drug discovery. Inevitably, the preferred ring system for one endpoint may prove detrimental to another, thus necessitating a holistic, multiple endpoint optimization approach for finding the ideal replacement. Accordingly, we… (More)
DOI: 10.1016/j.bmc.2016.11.004

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Cite this paper

@article{Chang2017AMM, title={A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.}, author={George Chang and Kim Huard and Gregory W. Kauffman and Antonia F Stepan and Christopher E. Keefer}, journal={Bioorganic & medicinal chemistry}, year={2017}, volume={25 1}, pages={381-388} }