A multi-dataset data-collection strategy produces better diffraction data

  title={A multi-dataset data-collection strategy produces better diffraction data},
  author={Zhi-Jie Liu and Lirong Chen and Dong Wu and Wei Ding and Hua Zhang and Weihong Zhou and Zhengqing Fu and Bi-Cheng Wang},
  booktitle={Acta crystallographica. Section A, Foundations of crystallography},
A multi-dataset (MDS) data-collection strategy is proposed and analyzed for macromolecular crystal diffraction data acquisition. The theoretical analysis indicated that the MDS strategy can reduce the standard deviation (background noise) of diffraction data compared with the commonly used single-dataset strategy for a fixed X-ray dose. In order to validate the hypothesis experimentally, a data-quality evaluation process, termed a readiness test of the X-ray data-collection system, was… CONTINUE READING

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Publications referenced by this paper.
Showing 1-6 of 6 references


  • M.G.
  • Mol. Biol. 289, 83–92. Fu, Z.-Q., Rose, J. P…
  • 1999
Highly Influential
4 Excerpts

Progress Towards Routine Soft X - ray Structure Determination at UGA and SER - CAT

  • G. N. Sarma, P. A. Karplus
  • Annual Meeting of the American Crystallographic…
  • 2007

Acta Cryst

  • D.J.
  • D59, 1943–1957. Acta Cryst. (2011). A67, 544–549
  • 2003


  • Wang, B.-C.
  • Struct. Biol. 8, 156–160. Yang, C., Pflugrath, J…
  • 2001

Acta Cryst . D 59 , 1943 – 1957

  • J. W. Pflugrath, D. A. Courville, C. N. Stence, J. D. Ferrara
  • Nat . Struct . Biol .

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