A multi-centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion.

@article{Lozano2011AMS,
  title={A multi-centre study of therapeutic efficacy and safety of platelet components treated with amotosalen and ultraviolet A pathogen inactivation stored for 6 or 7 d prior to transfusion.},
  author={Miguel Lozano and Folke Knutson and Ren{\'e} Tardivel and Joan Cid and Rosa Mar{\'i}a Maym{\'o} and Helena L{\"o}f and Huw Roddie and Jane Pelly and Anthony Docherty and Charles D. Sherman and Lily Lin and Meisa Propst and Laurence Corash and Chris Prowse},
  journal={British journal of haematology},
  year={2011},
  volume={153 3},
  pages={
          393-401
        }
}
Bacteria in platelet components (PC) may result in transfusion-related sepsis (TRS). Pathogen inactivation of PC with amotosalen (A-PC) can abrogate the risk of TRS and hence facilitate storage to 7 d. A randomized, controlled, double-blinded trial to evaluate the efficacy and safety of A-PC stored for 6-7 d was conducted. Patients were randomized to receive one transfusion of conventional PC (C-PC) or A-PC stored for 6-7 d. The primary endpoint was the 1 h corrected count increment (CCI) with… CONTINUE READING
Highly Cited
This paper has 25 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Preservation of stored blood with sulfanilamide

M. Novak
Journal of American Medical Association, • 1939
View 4 Excerpts
Highly Influenced

Clinical effectiveness of leukoreduced

J. L. Kerkhoffs, W. L. van Putten, +9 authors D. J. van Rhenen
2010
View 9 Excerpts
Highly Influenced

Clinical effectiveness of leukoreduced , pooled donor platelet concentrates , stored in plasma or additive solution with and without pathogen reduction

L. Lin, D. N. Cook, +21 authors L. Corash
British Journal of Haematology • 2010

Screening of single - donor apheresis platelets for bacterial contamination : the PASSPORT study results

A. F. Eder, J. M. Kennedy, +8 authors R. J. Benjamin
Transfusion • 2010