A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia

@article{Hijiya2009AMP,
  title={A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia},
  author={Nobuko Hijiya and P Gaynon and Elly Barry and L P Silverman and Blythe Thomson and Renzhu Chu and Todd C Cooper and Richard P. Kadota and Michael Rytting and Peter Steinherz and Violet Shen and Sima Jeha and Rekha Abichandani and William L Carroll},
  journal={Leukemia},
  year={2009},
  volume={23},
  pages={2259-2264}
}
This Phase I study of clofarabine with etoposide and cyclophosphamide for children with relapsed/refractory acute lymphoblastic leukemia (ALL) or acute myelogenous leukemia (AML) was conducted to determine the maximum tolerated dose (MTD), dose-limiting toxicities and the recommended phase 2 doses (RP2Ds). All three drugs were administered for five consecutive days in induction and four consecutive days in consolidation, for a maximum of eight cycles. A total of 25 patients (20 ALL and 5 AML… CONTINUE READING

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