A multi-analytical approach to better assess the keratan sulfate contamination in animal origin chondroitin sulfate.

@article{Restaino2017AMA,
  title={A multi-analytical approach to better assess the keratan sulfate contamination in animal origin chondroitin sulfate.},
  author={Odile Francesca Restaino and Rosario Finamore and Paola Diana and Mariacarmela Marseglia and Mario Vitiello and Angela Casillo and Emiliano Bedini and Michelangelo Parrilli and Maria Michela Corsaro and M. Trifuoggi and Mario de Rosa and Chiara Schiraldi},
  journal={Analytica chimica acta},
  year={2017},
  volume={958},
  pages={
          59-70
        }
}
Chondroitin sulfate is a glycosaminoglycan widely used as active principle of anti-osteoarthritis drugs and nutraceuticals, manufactured by extraction from animal cartilaginous tissues. During the manufacturing procedures, another glycosaminoglycan, the keratan sulfate, might be contemporarily withdrawn, thus eventually constituting a contaminant difficult to be determined because of its structural similarity. Considering the strict regulatory rules on the pureness of pharmaceutical grade… CONTINUE READING
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