A mouse muscle-adapted enterovirus 71 strain with increased virulence in mice.

@article{Wang2011AMM,
  title={A mouse muscle-adapted enterovirus 71 strain with increased virulence in mice.},
  author={Wei Wang and Jianying Duo and Jiangning Liu and Chun Mei Ma and Lianfeng Zhang and Qiang Wei and Chuan Qin},
  journal={Microbes and infection},
  year={2011},
  volume={13 10},
  pages={862-70}
}
Enterovirus 71 (EV71) infections can usually cause epidemic hand, foot, and mouth disease (HFMD), and occasionally lead to aseptic meningitis, encephalitis, and polio-like illness. Skeletal muscles have been thought to be crucial for the pathogenesis of EV71-related diseases. However, little is known about the virulence of mouse muscle-adapted EV71. The EV71 0805 were subjected to four passages in the mouse muscle to generate a mouse-adapted EV71 strain of 0805a. In comparison with the parental… CONTINUE READING