A mouse model recapitulating molecular features of human mesothelioma.

  title={A mouse model recapitulating molecular features of human mesothelioma.},
  author={Deborah A Altomare and Charles A. Vaslet and Kristine L. Skele and Assunta De Rienzo and Karthik Devarajan and Suresh C. Jhanwar and Andrea I McClatchey and Agnes B. Kane and Joseph R Testa},
  journal={Cancer research},
  volume={65 18},
Malignant mesothelioma has been linked to asbestos exposure and generally has a poor prognosis because it is often diagnosed in advanced stages and is refractory to conventional therapy. Human malignant mesotheliomas accumulate multiple somatic genetic alterations, including inactivation of the NF2 and CDKN2A/ARF tumor suppressor genes. To better understand the significance of NF2 inactivation in malignant mesothelioma and identify tumor suppressor gene alterations that cooperate with NF2 loss… CONTINUE READING