A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia.

@article{Sata2000AMM,
  title={A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia.},
  author={Masataka Sata and Yasuhiro Maejima and Fuminori Adachi and Keiko Fukino and Akio Saiura and Seiryo Sugiura and Teruhiko Aoyagi and Yasuharu Imai and Hideyuki Kurihara and Kensuke Kimura and Masao Omata and Mikio Makuuchi and Yasunobu Hirata and Ryozo Nagai},
  journal={Journal of molecular and cellular cardiology},
  year={2000},
  volume={32 11},
  pages={2097-104}
}
Genetically modified mice serve as a powerful tool to determine the role of specific molecules in a wide variety of biological phenomena including vascular remodeling. Several models of arterial injury have been proposed to analyze transgenic/knock-out mice, but many questions have been raised about their reproducibility and physiological significance. Here, we report a new mouse model of vascular injury that resembles balloon-angioplasty. A straight spring wire was inserted into the femoral… CONTINUE READING
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