A mouse model of rhabdomyosarcoma originating from the adipocyte lineage.

  title={A mouse model of rhabdomyosarcoma originating from the adipocyte lineage.},
  author={Mark E. Hatley and Wei Tang and Matthew R. Garcia and David Finkelstein and Douglas P Millay and Ning Liu and Jonathan Graff and Rene L. Galindo and Eric N Olson},
  journal={Cancer cell},
  volume={22 4},
Rhabdomyosarcoma (RMS) is an aggressive skeletal muscle-lineage tumor composed of malignant myoblasts that fail to exit the cell cycle and are blocked from fusing into syncytial muscle. Rhabdomyosarcoma includes two histolopathologic subtypes: alveolar rhabdomyosarcoma, driven by the fusion protein PAX3-FOXO1 or PAX7-FOXO1, and embryonal rhabdomyosarcoma (ERMS), which is genetically heterogeneous. Here, we show that adipocyte-restricted activation of Sonic hedgehog signaling through expression… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2003
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