A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor.

@article{Hayashi1996AMM,
  title={A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor.},
  author={Yasuhide Hayashi and Dimitra Mangoura and Samuel Refetoff},
  journal={Molecular endocrinology},
  year={1996},
  volume={10 1},
  pages={100-6}
}
Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome characterized by hyposensitivity to thyroid hormone caused by mutations in the thyroid hormone receptor-beta (TR beta) gene. Replication-defective recombinant adenoviruses were constructed that express the human wild-type (WT) TR beta, a human mutant TR beta identified in a family with RTH, and luciferase under the control of thyroid hormone (Luc). The efficient introduction and expression of these recombinant genes into… CONTINUE READING

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