A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide

@inproceedings{Williams2013AMM,
  title={A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide},
  author={Jonathan Mark Williams and Carrie A Duckworth and A J M Watson and Mark R Frey and Jennifer C Miguel and Michael D Burkitt and Robert Sutton and Kevin R. Hughes and Lindsay J Hall and Jorge H Caama{\~n}o and Barry James Campbell and D Mark Pritchard},
  booktitle={Disease models & mechanisms},
  year={2013}
}
The gut barrier, composed of a single layer of intestinal epithelial cells (IECs) held together by tight junctions, prevents the entrance of harmful microorganisms, antigens and toxins from the gut lumen into the blood. Small intestinal homeostasis is normally maintained by the rate of shedding of senescent enterocytes from the villus tip exactly matching the rate of generation of new cells in the crypt. However, in various localized and systemic inflammatory conditions, intestinal homeostasis… CONTINUE READING

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