A mouse model of paralytic myelitis caused by enterovirus D68

  title={A mouse model of paralytic myelitis caused by enterovirus D68},
  author={Alison M Hixon and Guixia Yu and J. Smith Leser and Shigeo Yagi and Penny Clarke and Charles Y Chiu and Kenneth L. Tyler},
  booktitle={PLoS pathogens},
In 2014, the United States experienced an epidemic of acute flaccid myelitis (AFM) cases in children coincident with a nationwide outbreak of enterovirus D68 (EV-D68) respiratory disease. Up to half of the 2014 AFM patients had EV-D68 RNA detected by RT-PCR in their respiratory secretions, although EV-D68 was only detected in cerebrospinal fluid (CSF) from one 2014 AFM patient. Given previously described molecular and epidemiologic associations between EV-D68 and AFM, we sought to develop an… CONTINUE READING
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