A mouse model of intracerebral hemorrhage using autologous blood infusion

@article{Rynkowski2008AMM,
  title={A mouse model of intracerebral hemorrhage using autologous blood infusion},
  author={M. Rynkowski and G. Kim and R. Komotar and M. Otten and A. Ducruet and B. Zacharia and C. Kellner and D. Hahn and M. Merkow and M. Garrett and R. Starke and Byung-Moon Cho and S. Sosunov and E. Connolly},
  journal={Nature Protocols},
  year={2008},
  volume={3},
  pages={122-128}
}
  • M. Rynkowski, G. Kim, +11 authors E. Connolly
  • Published 2008
  • Biology, Medicine
  • Nature Protocols
  • The development of controllable and reproducible animal models of intracerebral hemorrhage (ICH) is essential for the systematic study of the pathophysiology and treatment of hemorrhagic stroke. In recent years, we have used a modified version of a murine ICH model to inject blood into mouse basal ganglia. According to our protocol, autologous blood is stereotactically infused in two stages into the right striatum to mimic the natural events of hemorrhagic stroke. Following ICH induction… CONTINUE READING
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    References

    SHOWING 1-10 OF 58 REFERENCES
    Intracerebral Hemorrhage in Mice: Model Characterization and Application for Genetically Modified Mice
    • 98
    • PDF
    Experimental animal models of intracerebral hemorrhage.
    • 100
    Comparison of brain cell death and inflammatory reaction in three models of intracerebral hemorrhage in adult rats.
    • M. Xue, M. D. Del Bigio
    • Medicine
    • Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
    • 2003
    • 73