A mouse model of human repetitive mild traumatic brain injury.

  title={A mouse model of human repetitive mild traumatic brain injury.},
  author={M. J. Kane and Mariana Angoa-P{\'e}rez and Denise Isabelle Briggs and David C. Viano and Christian W. Kreipke and Donald M Kuhn},
  journal={Journal of neuroscience methods},
  volume={203 1},
A novel method for the study of repetitive mild traumatic brain injury (rmTBI) that models the most common form of head injury in humans is presented. Existing animal models of TBI impart focal, severe damage unlike that seen in repeated and mild concussive injuries, and few are configured for repetitive application. Our model is a modification of the Marmarou weight drop method and allows repeated head impacts to lightly anesthetized mice. A key facet of this method is the delivery of an… CONTINUE READING


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