A mouse model for latent tuberculosis.

  title={A mouse model for latent tuberculosis.},
  author={Sabai Phyu and Tehmina Mustafa and Tor Hofstad and Rune Nilsen and Richard Fosse and Gunnar Bjune},
  journal={Scandinavian journal of infectious diseases},
  volume={30 1},
The aim of the study was to establish a reproducible murine model for latent tuberculosis. We propose an operational definition of latent murine tuberculosis as a stable Mycobacterium-tuberculosis count in lungs and spleens without clinical signs or obvious histopathological changes in the lungs over a long period of time and without spontaneous reactivation of disease. B6D2F1Bom mice were inoculated with a wide range of Mycobacterium tuberculosis doses intraperitoneally or intravenously and… CONTINUE READING