A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.

@article{Srinivasan2003AMM,
  title={A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2.},
  author={Sudha Srinivasan and Martha A Hanes and Tayeashai Dickens and Mary E M Porteous and Suk Paul Oh and Laura P. Hale and Douglas A. Marchuk},
  journal={Human molecular genetics},
  year={2003},
  volume={12 5},
  pages={473-82}
}
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal-dominant disorder characterized by the age-dependent development of focal arteriovenous malformations and telangiectases. HHT type 2 is caused by loss of function mutations in activin receptor-like kinase 1 (ACVRL1 or ALK1). However, the factors that initiate lesion formation and those that influence disease progression remain unknown. Because heterozygous mice contain the appropriate genotype for an animal model of this disorder, mice… CONTINUE READING
72 Citations
45 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 72 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Similar Papers

Loading similar papers…