A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9.

@article{Carroll2016AMM,
  title={A mouse model for adult cardiac-specific gene deletion with CRISPR/Cas9.},
  author={Kelli Jane Carroll and Catherine A Makarewich and John R McAnally and Douglas M. Anderson and Lorena Zentilin and Ning Liu and Mauro Giacca and Rhonda Bassel-Duby and Eric N Olson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 2},
  pages={
          338-43
        }
}
Clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)9 genomic editing has revolutionized the generation of mutant animals by simplifying the creation of null alleles in virtually any organism. However, most current approaches with this method require zygote injection, making it difficult to assess the adult, tissue-specific functions of genes that are widely expressed or which cause embryonic lethality when mutated. Here, we describe the generation of cardiac… CONTINUE READING
Tweets
This paper has been referenced on Twitter 8 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Biotechnology. A prudent path forward for genomic engineering and germline gene modification

  • D Baltimore
  • Science
  • 2015
1 Excerpt

Similar Papers

Loading similar papers…