A mouse model for Niemann-Pick disease. Influence of genetic background on disease expression in spm/spm mice.

Abstract

Sphingomyelinosis (spm), an autosomal recessive mutation in mice originally occurred in the C57BL/KsJ inbred strain. Spm/spm mice of this genetic background show striking hepatosplenomegaly with a marked accumulation of sphingomyelin and cholesterol due to a deficiency of sphingomyelinase. However, in spm/spm mice of C57BL/6J and DBA/2J backgrounds… (More)

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@article{Miyawaki1986AMM, title={A mouse model for Niemann-Pick disease. Influence of genetic background on disease expression in spm/spm mice.}, author={Shuichi Miyawaki and Hideaki Yoshida and Saya Mitsuoka and Hirayuki Enomoto and Susumu Ikehara}, journal={The Journal of heredity}, year={1986}, volume={77 6}, pages={379-84} }