A mouse mammary epithelial cell line permissive for highly efficient human adenovirus growth.

@article{Wu2013AMM,
  title={A mouse mammary epithelial cell line permissive for highly efficient human adenovirus growth.},
  author={Chengjun Wu and Daniel {\"O}berg and Asif Rashid and Rajesh Kumar Gupta and Marco Mignardi and Staffan Johansson and G{\"o}ran Akusj{\"a}rvi and Catharina Svensson},
  journal={Virology},
  year={2013},
  volume={435 2},
  pages={363-71}
}
Although a few immunocompetent animal models to study the immune response against human adenoviruses (HAdV) are available, such as Syrian hamsters and cotton rats, HAdV replication is several logs lower compared to human control cells. We have identified a non-transformed mouse epithelial cell line (NMuMG) where HAdV-2 gene expression and progeny formation was as efficient as in the highly permissive human A549 cells. HAdV from species, D and E (HAdV-37 and HAdV-4, respectively) also caused a… CONTINUE READING

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