A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.

@article{Chu2009AMF,
  title={A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.},
  author={Jessie Chu and Nancy A. Hong and Claudio Akio Masuda and Brian V Jenkins and Keats A. Nelms and Christopher C. Goodnow and Richard J. Glynne and Hua Wu and Eliezer Masliah and Claudio A P Joazeiro and Steve A Kay},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 7},
  pages={2097-103}
}
A mouse neurological mutant, lister, was identified through a genome-wide N-ethyl-N-nitrosourea (ENU) mutagenesis screen. Homozygous lister mice exhibit profound early-onset and progressive neurological and motor dysfunction. lister encodes a RING finger protein, LISTERIN, which functions as an E3 ubiquitin ligase in vitro. Although lister is widely expressed in all tissues, motor and sensory neurons and neuronal processes in the brainstem and spinal cord are primarily affected in the mutant… CONTINUE READING
54 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Similar Papers

Loading similar papers…