A motility function for the paraflagellar rod of Leishmania parasites revealed by PFR-2 gene knockouts.

@article{Santrich1997AMF,
  title={A motility function for the paraflagellar rod of Leishmania parasites revealed by PFR-2 gene knockouts.},
  author={Cecilia Santrich and L. Ted Moore and Trevor Sherwin and Philippe Bastin and Charles J. Brokaw and Keith Gull and Jonathan H LeBowitz},
  journal={Molecular and biochemical parasitology},
  year={1997},
  volume={90 1},
  pages={95-109}
}
We demonstrate a functional role for the paraflagellar rod (PFR) in motility of Leishmania mexicana. The PFR is a complex cytoskeletal structure running parallel to the axoneme in the flagella of kinetoplastid protozoa. The PFR is composed of a latticework of protein filaments whose major constituents are two related proteins (PFR-1 and PFR-2 in Leishmania). The molecular details of their assembly into PFR filaments are unknown as is the biological function of the PFR. As an approach to… CONTINUE READING