A motif-based analysis of glycan array data to determine the specificities of glycan-binding proteins.

@article{Porter2010AMA,
  title={A motif-based analysis of glycan array data to determine the specificities of glycan-binding proteins.},
  author={Andrew Porter and Tingting Yue and Lee P Heeringa and Steven H Day and Edward Suh and Brian B. Haab},
  journal={Glycobiology},
  year={2010},
  volume={20 3},
  pages={369-80}
}
Glycan arrays have enabled detailed studies of the specificities of glycan-binding proteins. A challenge in the interpretation of glycan array data is to determine the specific features of glycan structures that are critical for binding. To address this challenge, we have developed a systematic method to interpret glycan array data using a motif-based analysis. Each glycan on a glycan array is classified according to its component sub-structures, or motifs. We analyze the binding of a given… CONTINUE READING

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