A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae

  title={A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae},
  author={Jose Luis Ramirez and Giselle de Almeida Oliveira and Eric Calvo and Jesmond Dalli and Romain Alexandre Colas and Charles Nicholas Serhan and Jose M.C. Ribeiro and Carolina Barillas-Mury},
  journal={Nature Communications},
Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember' a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that… 
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Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production.
  • D. PrescottD. McKay
  • Biology, Medicine
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  • 2011
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  • Biology
    Journal of bioenergetics and biomembranes
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