A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase.

@article{Wu2013AMS,
  title={A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase.},
  author={Pui-Kei Wu and Seung-Keun Hong and Sudhakar Veeranki and Mansi Karkhanis and Dmytro Starenki and Jos{\'e} Antonio Plaza and J I Park},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 20},
  pages={4051-67}
}
Dysregulated Raf/MEK/extracellular signal-regulated kinase (ERK) signaling, a common hallmark of tumorigenesis, can trigger innate tumor-suppressive mechanisms, which must be inactivated for carcinogenesis to occur. This innate tumor-suppressive signaling may provide a potential therapeutic target. Here we report that mortalin (HSPA9/GRP75/PBP74) is a novel… CONTINUE READING