A morphometric study of light-induced damage in transgenic rat models of retinitis pigmentosa.

@article{Vaughan2003AMS,
  title={A morphometric study of light-induced damage in transgenic rat models of retinitis pigmentosa.},
  author={Dana K. Vaughan and Sylvie F Coulibaly and Ruth M Darrow and Daniel Organisciak},
  journal={Investigative ophthalmology & visual science},
  year={2003},
  volume={44 2},
  pages={848-55}
}
PURPOSE To determine relative susceptibility to, and regional variation of, light-induced retinal damage in two rhodopsin-mutant rat models of retinitis pigmentosa, using slow- and fast-degenerating lines. METHODS Transgenic S334ter (lines 4 and 9) and P23H (lines 2 and 3) rats were reared in dim cyclic light or darkness and then exposed to intense green light for 1 to 8 hours. Sections along the vertical meridian were collected for retinal morphology and photoreceptor morphometry 2 weeks… CONTINUE READING

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