A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue.

@article{Jansen2014AMA,
  title={A morphological and functional comparison of proximal tubule cell lines established from human urine and kidney tissue.},
  author={Jeroen C. Jansen and Carolien M S Schophuizen and Martijn J Wilmer and Shadi Lahham and Henricus A. M. Mutsaers and Jack F. M. Wetzels and Ruud A. Bank and L. P. van den Heuvel and Joost G. J. Hoenderop and Rosalinde Masereeuw},
  journal={Experimental cell research},
  year={2014},
  volume={323 1},
  pages={
          87-99
        }
}
Promising renal replacement therapies include the development of a bioartificial kidney using functional human kidney cell models. In this study, human conditionally immortalized proximal tubular epithelial cell (ciPTEC) lines originating from kidney tissue (ciPTEC-T1 and ciPTEC-T2) were compared to ciPTEC previously isolated from urine (ciPTEC-U). Subclones of all ciPTEC isolates formed tight cell layers on Transwell inserts as determined by transepithelial resistance, inulin diffusion, E… CONTINUE READING
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