A morphogenetic role for acetylcholine in mouse cerebral neocortex

  title={A morphogenetic role for acetylcholine in mouse cerebral neocortex},
  author={Christine F. Hohmann},
  journal={Neuroscience & Biobehavioral Reviews},
Recently, cholinergic afferents to cerebral cortex have met renewed attention regarding the regulation of plasticity as well as cognitive processing. My laboratory has developed a mouse neonatal basal forebrain lesion paradigm that has contributed considerably to the understanding of cholinergic mechanisms in cortical development. We have shown that transient cholinergic deafferentation, beginning at birth, precipitates alterations in neuronal differentiation and synaptic connectivity that… CONTINUE READING


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