A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation.

  title={A monounsaturated fatty acid (oleic acid) modulates electrical activity in atrial myocytes with calcium and sodium dysregulation.},
  author={Yung-Kuo Lin and Yao-Chang Chen and Y. Kao and Chin-Feng Tsai and Y. Yeh and J. Huang and Chen-Chuan Cheng and S. Chen and Y. Chen},
  journal={International journal of cardiology},
  volume={176 1},
  • Yung-Kuo Lin, Yao-Chang Chen, +6 authors Y. Chen
  • Published 2014
  • Medicine
  • International journal of cardiology
  • BACKGROUND Obesity and metabolic syndrome are important risk factors for atrial fibrillation. High plasma concentrations of monounsaturated fatty acids, including oleic acid (OLA), are frequently noted in obese individuals and patients with metabolic syndrome. However, it is not clear whether monounsaturated fatty acids (MUFAs) can directly modulate the electrophysiological characteristics of atrial myocytes. METHODS Whole-cell patch clamp, indo-1 fluorescence, and Western blot analyses were… CONTINUE READING
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