A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.

@article{Whorton2007AMG,
  title={A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein.},
  author={Matthew R. Whorton and Michael P. Bokoch and S\oren G. F. Rasmussen and Bo Huang and Richard N. Zare and Brian K. Kobilka and Roger K Sunahara},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 18},
  pages={7682-7}
}
G protein-coupled receptors (GPCRs) respond to a diverse array of ligands, mediating cellular responses to hormones and neurotransmitters, as well as the senses of smell and taste. The structures of the GPCR rhodopsin and several G proteins have been determined by x-ray crystallography, yet the organization of the signaling complex between GPCRs and G proteins is poorly understood. The observations that some GPCRs are obligate heterodimers, and that many GPCRs form both homo- and heterodimers… CONTINUE READING

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