A monolithic silicon optoelectronic transducer as a real-time affinity biosensor.

@article{Misiakos2004AMS,
  title={A monolithic silicon optoelectronic transducer as a real-time affinity biosensor.},
  author={Konstantinos Misiakos and Sotirios E. Kakabakos and Panagiota S. Petrou and Hans H. Ruf},
  journal={Analytical chemistry},
  year={2004},
  volume={76 5},
  pages={1366-73}
}
An optical real-time affinity biosensor, which is based on a monolithic silicon optoelectronic transducer and a microfluidic module, is described. The transducer monolithically integrates silicon avalanche diodes as light sources, silicon nitride optical fibers, and p/n junction detectors and efficiently intercouples these elements through a self-alignment technique. The transducer surface is hydrophilized by oxygen plasma treatment, silanized with (3-aminopropyl)triethoxysilane and… CONTINUE READING
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