A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44.

@article{Shepley1994AMA,
  title={A monoclonal antibody that blocks poliovirus attachment recognizes the lymphocyte homing receptor CD44.},
  author={M P Shepley and Vincent R. Racaniello},
  journal={Journal of virology},
  year={1994},
  volume={68 3},
  pages={1301-8}
}
A monoclonal antibody, AF3, was previously shown to specifically inhibit poliovirus binding to HeLa cells and to detect a 100-kDa glycoprotein only in cell lines and tissues permissive for poliovirus infection. These results suggested that the 100-kDa protein may be involved in the pathogenesis of poliomyelitis and the cellular function of the poliovirus receptor site. To study further the role of the 100-kDa protein in poliovirus attachment, immunoaffinity purification, amino acid sequencing… CONTINUE READING
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Molecular cloning of CD44RI and CD44R2, two novel isoforms of the human CD44 lymphocyte "homing" receptor expressed on hemopoietic cells

  • G. J. Dougherty, P. M. Lansdorp, D. L. Cooper, R. K. Humphries
  • J. Exp. Med
  • 1991

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