A monoclonal antibody specific for the amino terminal cleavage site of procollagen type I.

@article{Foellmer1983AMA,
  title={A monoclonal antibody specific for the amino terminal cleavage site of procollagen type I.},
  author={Harald G. Foellmer and Kazuyoshi Kawahara and Joseph A. Madri and Heinz Furthmayr and Rupert Timpl and L Tuderman},
  journal={European journal of biochemistry},
  year={1983},
  volume={134 1},
  pages={183-9}
}
A monoclonal mouse IgG1 antibody was produced against the aminopropeptide of dermatosparactic sheep procollagen type I by using the hybridoma technique. Radioimmunoassays demonstrated an apparent affinity constant of 10(8) l X mol-1. The antibody reacted with a 19-amino-acid-long sequence spanning the procollagen N-proteinase cleavage site with stronger binding to structures contributed by the aminopropeptide. The antibody showed strong cross-reactions with similar antigens of bovine, human or… CONTINUE READING

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