A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s)

@article{Ciccone1988AMA,
  title={A monoclonal antibody specific for a common determinant of the human T cell receptor gamma/delta directly activates CD3+WT31- lymphocytes to express their functional program(s)},
  author={Ermanno 5 Ciccone and Silvano Ferrini and Cristina Bottino and Oriane Viale and Ignazia Prigione and Giuseppe Pantaleo and Giuseppe Tambussi and Alessandro Moretta},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={168},
  pages={1 - 11}
}
In an attempt to select mAbs specific for human TCR-gamma/delta, a polyclonal CD3+ 4-8-WT31- (TCR-gamma/delta+) cell line (MV1) was used for mice immunization. An mAb, termed BB3, reacted with MV1 cells but not with a large panel of CD3+ WT31+ (TCR-alpha/beta+) cell populations or clones. In addition, BB3 mAb reacted with the majority of CD3+ WT31- clones derived from six different donors. Double-color fluorescence experiments and FACS analysis showed that BB3+ cells were restricted to the CD3… CONTINUE READING
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