A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor.

@article{Jungbluth2003AMA,
  title={A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor.},
  author={Achim A. Jungbluth and Elisabeth Stockert and H.-J. Huang and Vincent Peter Collins and Keren Coplan and Kristin Iversen and Denise Kolb and Terrance J Johns and Andrew Mark Scott and William J. Gullick and Gerd Ritter and Leonard Cohen and Matthew J. Scanlan and Webster K Cavenee and L. John Old},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 2},
  pages={639-44}
}
Epidermal growth factor receptor (EGFR) has attracted considerable attention as a target for cancer therapy. Wild-type (wt)EGFR is amplified/overexpressed in a number of tumor types, and several mutant forms of the coding gene have been found, with DeltaEGFR, a deletion mutation lacking exons 2-7 of the external domain, being the most common and particularly associated with glioblastoma. We generated monoclonal antibodies (mAbs) against NR6(DeltaEGFR) (mouse fibroblast line NR6 transfected with… CONTINUE READING