A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase.

@article{Endemann1991AMA,
  title={A monoclonal antibody distinguishes two types of phosphatidylinositol 4-kinase.},
  author={G C Endemann and Andrea Graziani and Lewis C. Cantley},
  journal={The Biochemical journal},
  year={1991},
  volume={273(Pt 1)},
  pages={63-6}
}
A monoclonal antibody has been developed against the type II PtdIns 4-kinase from bovine brain. This antibody, 4C5G, causes greater than 90% inhibition of the type II PtdIns 4-kinase from bovine brain, rat brain and human erythrocytes. However, it fails to inhibit type III PtdIns 4-kinase from bovine brain or PtdIns 3-kinase from rat liver. These results suggest that type II and type III PtdIns 4-kinases are distinct gene products, and that 4C5G will be useful in studying the function of the… CONTINUE READING

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